The Market Square branch of First Bank was robbed shortly before 11 a.m. Wednesday morning by a gun-toting man.
It was unclear how much money was taken from the bank, located just east of the bungalow at Rothschild Francis Square.
WVWI Radio One is quoting unnamed sources as saying the gunman entered the bank office but instead of proceeding to the teller area, pointed the gun at employees on the customer service platform just inside the main entrance.
Police sources told Radio One that the gunman fled in an early model, red Pontiac Firebird. There were no immediate reports of injuries.
Police were at the scene with agents of the V.I. Safe Streets Task Force, who will likely take the lead in the investigation.
Anyone with information should call emergency 911, the Police Investigation Bureau at 774-4050 or the Safe Streets Task Force at 776-9440.